Ophthalmic involvement in VEXAS syndrome and its influence on mortality: insights from the international AIDA network registry - Takeaways - MDSpire

Ophthalmic involvement in VEXAS syndrome and its influence on mortality: insights from the international AIDA network registry

  • By

  • Jurgen Sota

  • Andrea Hinojosa-Azaola

  • Eduardo Martín-Nares

  • Paolo Sfriso

  • Sara Bindoli

  • Pravin Hissaria

  • Mark Beecher

  • José Hernández-Rodríguez

  • Verónica Gómez-Caverzaschi

  • Micol Frassi

  • Francesca Crisafulli

  • Lorenzo Dagna

  • Corrado Campochiaro

  • Serena Bugatti

  • Alessandra Milanesi

  • Guillermo Ruiz-Irastorza

  • Adriana Soto-Peleteiro

  • Matteo Piga

  • Ombretta Viapiana

  • Abdurrahman Tufan

  • Ertugrul Cagri Bolek

  • Paola Triggianese

  • Marcella Prete

  • Jessica Sblachiero

  • Valeria Caggiano

  • Antonio Vitale

  • Henrique Ayres Mayrink Giardini

  • Giuseppe Lopalco

  • Fabrizio Conti

  • Paolo Moscato

  • Chiara Cardamone

  • Ewa Wiesik-Szewczy

  • Andrés González-García

  • Amato De Paulis

  • Rosetta Vitetta

  • Perla Ayumi Kawakami-Campos

  • Alessandra Brancaleoni

  • Andrea Mercanti

  • Alessandra Renieri

  • Monica Bocchia

  • Gaafar Ragab

  • Vishali Gupta

  • Alejandra de-la-Torre

  • Bruno Frediani

  • Carmelo Gurnari

  • Luca Cantarini

  • Claudia Fabiani

  • June 19, 2026

  • 0 min

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  • 1

    Orbital inflammation is the most common ocular manifestation in VEXAS syndrome, affecting nearly half of patients.

  • 2

    Ophthalmic involvement is significantly associated with relapsing polychondritis and higher mortality rates.

  • 3

    Patients with ocular involvement had a relative risk of 5.87 for fatal outcomes compared to those without.

  • 4

    Treatment with glucocorticosteroids resulted in a full or partial response in 66.7% of cases with ophthalmic involvement.

  • 5

    Ophthalmic inflammation typically presents at disease onset or before diagnosis, indicating its diagnostic importance.

Original Source(s)

Ophthalmic involvement in VEXAS syndrome and its influence on mortality: insights from the international AIDA network registry

  • by Jurgen Sota, Andrea Hinojosa-Azaola, Eduardo Martín-Nares, Paolo Sfriso, Sara Bindoli, Pravin Hissaria, Mark Beecher, José Hernández-Rodríguez, Verónica Gómez-Caverzaschi, Micol Frassi, Francesca Crisafulli, Lorenzo Dagna, Corrado Campochiaro, Serena Bugatti, Alessandra Milanesi, Guillermo Ruiz-Irastorza, Adriana Soto-Peleteiro, Matteo Piga, Ombretta Viapiana, Abdurrahman Tufan, Ertugrul Cagri Bolek, Paola Triggianese, Marcella Prete, Jessica Sblachiero, Valeria Caggiano, Antonio Vitale, Henrique Ayres Mayrink Giardini, Giuseppe Lopalco, Fabrizio Conti, Paolo Moscato, Chiara Cardamone, Ewa Wiesik-Szewczy, Andrés González-García, Amato De Paulis, Rosetta Vitetta, Perla Ayumi Kawakami-Campos, Alessandra Brancaleoni, Andrea Mercanti, Alessandra Renieri, Monica Bocchia, Gaafar Ragab, Vishali Gupta, Alejandra de-la-Torre, Bruno Frediani, Carmelo Gurnari, Luca Cantarini, Claudia Fabiani

  • June 19, 2026

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