Urine Metabolites of Suspected Community-Acquired Pneumonia - Takeaways - MDSpire

Urine Metabolites of Suspected Community-Acquired Pneumonia

  • By

  • Lilliam Ambroggio

  • Todd A Florin

  • Kayla Williamson

  • Grace Bosma

  • Brandie D Wagner

  • Larisa Yeomans

  • Jae Hyun Kim

  • Heidi Sucharew

  • Maurizio Macaluso

  • Richard M Ruddy

  • Kathleen A Stringer

  • Samir S Shah

  • February 12, 2025

  • 0 min

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  • 1

    The study aimed to identify urinary metabolites that differentiate children with suspected community-acquired pneumonia (CAP) from healthy controls.

  • 2

    A total of 253 children with suspected CAP and 122 community-based controls were included in the analysis.

  • 3

    Metabolomics revealed key metabolites such as 2-aminobutyrate and fumarate that accurately discriminate between CAP and healthy children.

  • 4

    The metabolite-only model achieved an AUC of 0.97, comparable to the combined model's AUC of 0.99, indicating strong diagnostic potential.

  • 5

    This study highlights the potential of urinary metabolite profiling as a noninvasive diagnostic tool for pediatric CAP.

Original Source(s)

Urine Metabolites of Suspected Community-Acquired Pneumonia

  • by Lilliam Ambroggio, Todd A Florin, Kayla Williamson, Grace Bosma, Brandie D Wagner, Larisa Yeomans, Jae Hyun Kim, Heidi Sucharew, Maurizio Macaluso, Richard M Ruddy, Kathleen A Stringer, Samir S Shah

  • February 12, 2025

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