Effect of anakinra on cytokine storm during sepsis-induced multiple organ dysfunction syndrome: case report and preclinical investigation - Takeaways - MDSpire
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Impact of Anakinra on Cytokine Storm in Sepsis-Related Multiple Organ Dysfunction Syndrome: A Case Study and Preclinical Analysis

  • By

  • Rebecca M. Blade

  • Sarah P. Lecher

  • Todd M. Umstead

  • Zissis C. Chroneos

  • Cainan Riccio-Baum

  • S. Rameeza Allie

  • Timothy J. Hahn

  • Daniel J. McKeone

  • Jessica E. Ericson

  • Theodore DeMartini

  • Debbie Spear

  • E. Scott Halstead

  • August 19, 2026

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  • 1

    A 9-year-old female patient developed multiple organ dysfunction syndrome (MODS) following a human metapneumovirus infection.

  • 2

    Treatment included extracorporeal life support (ECLS), anakinra, and therapeutic plasma exchange (TPE) for managing her condition.

  • 3

    Anakinra administration resulted in significant reductions in IL-6 and IL-8 concentrations, indicating its potential role in cytokine storm management.

  • 4

    The patient showed improvement in organ function and hemodynamics after treatment, ultimately leading to her discharge from rehabilitation.

  • 5

    Cytokine analysis suggested that IL-6 levels may be influenced by the synergistic actions of IL-1 and TNF in sepsis-related MODS.

Original Source(s)

Effect of anakinra on cytokine storm during sepsis-induced multiple organ dysfunction syndrome: case report and preclinical investigation

  • by Rebecca M. Blade, Sarah P. Lecher, Todd M. Umstead, Zissis C. Chroneos, Cainan Riccio-Baum, S. Rameeza Allie, Timothy J. Hahn, Daniel J. McKeone, Jessica E. Ericson, Theodore DeMartini, Debbie Spear, E. Scott Halstead

  • August 19, 2026

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