A draft plasma proteome atlas detected 179,049 potential proteoforms across 5,077 protein groups.
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Researchers classified 44,083 proteoforms from 2,089 protein groups as high confidence after detection in at least 3 of 4 replicate gel experiments.
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The median number of high-confidence proteoforms was 11 per protein, with the greatest diversity among abundant proteins and those involved in nutrient transport, clotting, and complement immunity.
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Olink and SomaScan measurements generally agreed more closely for abundant proteins with low or moderate proteoform diversity, while low concentrations often accompanied poor agreement.
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The atlas is an initial reference because most proteoforms were not fully identified, and low-abundance or disease-associated forms may be underrepresented.
