Local Circadian Clocks Are Desynchronized From the Central Circadian Pacemaker in a Mouse Model of Inflammatory Arthritis - Takeaways - MDSpire

Peripheral Circadian Rhythms Disrupted Relative to the Central Circadian Regulator in a Mouse Model of Inflammatory Arthritis

  • By

  • Lance A. Riley

  • Luke E. Springer

  • Sandra Paola Cárdenas-García

  • Tatiana Simon

  • Farshid Guilak

  • Christine T. N. Pham

  • Erik D. Herzog

  • July 1, 2026

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  • 1

    Rheumatoid arthritis affects approximately 1.5 million adults in the U.S. and incurs an annual cost of $24 billion.

  • 2

    The K/BxN serum transfer arthritis mouse model mimics various stages of rheumatoid arthritis, including initiation and resolution.

  • 3

    Continuous actigraphy was used to monitor locomotion in mice, providing a noninvasive measure of rheumatoid arthritis progression.

  • 4

    Inflammatory arthritis disrupts local circadian rhythms in affected joints while largely preserving central diurnal timing.

  • 5

    Dexamethasone treatment was administered to evaluate its effects on disease measures in the K/BxN mouse model.

Original Source(s)

Local Circadian Clocks Are Desynchronized From the Central Circadian Pacemaker in a Mouse Model of Inflammatory Arthritis

  • by Lance A. Riley, Luke E. Springer, Sandra Paola Cárdenas-García, Tatiana Simon, Farshid Guilak, Christine T. N. Pham, Erik D. Herzog

  • July 1, 2026

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