Integrated transcriptomic profiling of rectal and adipose HIV-1 reservoirs relative to matched PBMCs in ART-treated individuals - Takeaways - MDSpire

Integrated transcriptomic profiling of rectal and adipose HIV-1 reservoirs relative to matched PBMCs in ART-treated individuals

  • By

  • Jie Qin

  • Peiming Huang

  • Minghua Chen

  • Hua Zong

  • Jingjing Luo

  • Jianteng Zeng

  • Xu Zhang

  • Shiting Huang

  • Jianqiang Zou

  • Xin He

  • Shuangxin Wu

  • Liqin Sun

  • Ting Pan

  • July 7, 2026

  • 0 min

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  • 1

    HIV-1 persists in anatomical reservoirs, particularly in rectal and adipose tissues, despite suppressive antiretroviral therapy.

  • 2

    Droplet digital PCR analysis revealed significantly higher viral DNA loads in rectal and adipose tissues compared to matched PBMCs.

  • 3

    Transcriptomic profiling showed distinct host responses in rectal and adipose reservoirs, highlighting ECM reorganization and cell cycle dysregulation.

  • 4

    The PI3K-Akt signaling pathway was identified as a common feature across rectal and adipose tissue transcriptomes.

  • 5

    Validation experiments confirmed tissue-specific expression patterns of fibrosis-associated gene COL1A1 and leukocyte marker CX3CR1.

Original Source(s)

Integrated transcriptomic profiling of rectal and adipose HIV-1 reservoirs relative to matched PBMCs in ART-treated individuals

  • by Jie Qin, Peiming Huang, Minghua Chen, Hua Zong, Jingjing Luo, Jianteng Zeng, Xu Zhang, Shiting Huang, Jianqiang Zou, Xin He, Shuangxin Wu, Liqin Sun, Ting Pan

  • July 7, 2026

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