Preclinical evaluation of a multi-epitope mRNA vaccine platform for broad and durable SARS-CoV-2 protection

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CoV2-BMEPu is a multi-epitope mRNA vaccine designed to enhance protection against SARS-CoV-2 by targeting conserved viral regions.
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The vaccine incorporates immunodominant regions from Spike, Membrane, and Nucleocapsid proteins, along with selected receptor-binding domain segments.
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In preclinical studies, CoV2-BMEPu elicited robust antibody responses and strong CD8⁺ T cell responses in mouse models.
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Immunization with CoV2-BMEPu provided complete protection against lethal SARS-CoV-2 challenges in transgenic mice.
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The findings support CoV2-BMEPu as a promising next-generation vaccine strategy for broad and durable immunity against SARS-CoV-2 variants.

Frontiers In Immunology

by Laura Marcos-Villar, Beatriz Perdiguero, Laura Sin, Enrique Álvarez, Sara Flores, José M. Casasnovas, Tirso Pons, Carlos Oscar S. Sorzano, Daniel del Hoyo, Philipp Lapuhs, María J. Alonso, Mariano Esteban, Carmen Elena Gómez
May 5, 2026

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