Global Practice Variation in the Management of Clostridioides difficile Infections: An International Cross-Sectional Survey of Clinicians - Takeaways - MDSpire

Global Practice Variation in the Management of Clostridioides difficile Infections: An International Cross-Sectional Survey of Clinicians

  • By

  • Connor Prosty

  • Émilie Bortolussi-Courval

  • Jimmy Lee

  • Todd C Lee

  • Emily G McDonald

  • April 24, 2025

  • 0 min

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  • 1

    Clostridioides difficile infections (CDIs) pose significant global morbidity, mortality, and economic challenges, with an estimated 8 million cases annually.

  • 2

    A survey of 359 healthcare professionals from 31 countries revealed substantial international variability in CDI diagnosis, treatment, and prophylaxis practices.

  • 3

    Seventy-five percent of respondents utilized a 2-step CDI diagnostic algorithm, but there was heterogeneity in assay types and treatment protocols.

  • 4

    Secondary CDI prophylaxis was most prevalent in North America (84.1%), contrasting with lower rates in Europe (31.0%) and other continents (50.0%).

  • 5

    The findings indicate critical knowledge gaps and highlight the need for randomized controlled trials to establish consistent international CDI management guidelines.

Original Source(s)

Global Practice Variation in the Management of Clostridioides difficile Infections: An International Cross-Sectional Survey of Clinicians

  • by Connor Prosty, Émilie Bortolussi-Courval, Jimmy Lee, Todd C Lee, Emily G McDonald

  • April 24, 2025

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