CX3CR1 and CCR2: dynamic myeloid cell states across inflammatory diseases with implications for oral health and disease - Takeaways - MDSpire

CX3CR1 and CCR2: dynamic myeloid cell states across inflammatory diseases with implications for oral health and disease

  • By

  • Yun-Ji Lim

  • Tae Sung Kim

  • June 17, 2026

  • 0 min

Share

  • 1

    CCR2 and CX3CR1 are key chemokine receptors that regulate inflammatory monocyte recruitment and tissue macrophage retention.

  • 2

    These receptors function as dynamic regulators of myeloid cell states, influencing inflammation outcomes rather than fixed immune cell markers.

  • 3

    The recruitment-to-residency axis describes the transition of myeloid cells from inflammatory recruitment to tissue adaptation.

  • 4

    Dysregulated CCR2-CX3CR1 dynamics contribute to chronic inflammatory diseases like periodontitis, leading to tissue destruction.

  • 5

    Understanding the interplay between CX3CR1 and CCR2 can inform precision immunomodulatory strategies for oral and systemic health.

Original Source(s)

CX3CR1 and CCR2: dynamic myeloid cell states across inflammatory diseases with implications for oral health and disease

  • by Yun-Ji Lim, Tae Sung Kim

  • June 17, 2026

Related Content

Predicting survival in oral squamous cell carcinoma via integrated analysis of tumor budding and tertiary lymphoid structures

The Impact of Self-management Ability on Oral Frailty in Older Adults with Hypertension: The Chain Mediating Role of Anxiety and Nutritional Status

FDA Expands Marstacimab Indication in Hemophilia A and B

Phase 3 BASIS and BASIS KIDS data supported the expanded indication across pediatric and inhibitor-pretreated populations.