Activity-dependent adaptive deep brain stimulation improves gait in Parkinson’s disease - Takeaways - MDSpire

Activity-dependent adaptive deep brain stimulation improves gait in Parkinson’s disease

  • By

  • Stefano Scafa

  • Valeria de Seta

  • Ruijia Wang

  • Paula Sánchez López

  • Andrea Sánchez López

  • Camille Varescon

  • Icare Sakr

  • Nadia Bérard

  • Lea Bole-Feysot

  • Céline Deschenaux

  • Ian Enderli

  • Yohann Thenaisie

  • Morgane Burri

  • Frédéric Merlos

  • Vanessa Fleury

  • Benoit Wicki

  • Ettore Accolla

  • Andria Tziakouri

  • Cécile Hübsch

  • Mayte Castro Jiménez

  • Julien F. Bally

  • Alessandro Puiatti

  • Kyuhwa Lee

  • Henri Lorach

  • Antoine Collomb-Clerc

  • Jocelyne Bloch

  • Eduardo M. Moraud

  • June 15, 2026

  • 0 min

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  • 1

    Parkinson's disease causes significant locomotor deficits, with up to 90% of patients experiencing treatment-resistant impairments.

  • 2

    Conventional deep brain stimulation (DBS) often fails to address gait deficits and may worsen symptoms like postural instability.

  • 3

    Adaptive DBS (aDBS) strategies can outperform conventional DBS by dynamically adjusting stimulation parameters based on real-time activity.

  • 4

    The subthalamic nucleus (STN) encodes locomotor activities, enabling personalized aDBS therapies that improve both gait and cardinal motor symptoms.

  • 5

    A multimodal platform was developed to map STN dynamics to mobility activities, enhancing the understanding of therapeutic interactions in Parkinson's patients.

Original Source(s)

Activity-dependent adaptive deep brain stimulation improves gait in Parkinson’s disease

  • by Stefano Scafa, Valeria de Seta, Ruijia Wang, Paula Sánchez López, Andrea Sánchez López, Camille Varescon, Icare Sakr, Nadia Bérard, Lea Bole-Feysot, Céline Deschenaux, Ian Enderli, Yohann Thenaisie, Morgane Burri, Frédéric Merlos, Vanessa Fleury, Benoit Wicki, Ettore Accolla, Andria Tziakouri, Cécile Hübsch, Mayte Castro Jiménez, Julien F. Bally, Alessandro Puiatti, Kyuhwa Lee, Henri Lorach, Antoine Collomb-Clerc, Jocelyne Bloch, Eduardo M. Moraud

  • June 15, 2026

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