PIGL promotes the docetaxel resistance of prostate cancer and is regulated by E3 ubiquitin ligase HUWE1 - Takeaways - MDSpire

PIGL promotes the docetaxel resistance of prostate cancer and is regulated by E3 ubiquitin ligase HUWE1

  • By

  • Pan Gao

  • Bo-Han Lin

  • Zhi Zhang

  • Ze-Yu Yi

  • Zhi-Bin Ke

  • Zhong-Hua Zhu

  • Zhen Kang

  • Yong Wei

  • June 18, 2026

  • 0 min

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  • 1

    PIGL is highly expressed in prostate cancer and correlates with poor prognosis, particularly in docetaxel-resistant cases.

  • 2

    High PIGL expression promotes proliferation, migration, invasion, and resistance to docetaxel in prostate cancer cells.

  • 3

    HUWE1, identified as an E3 ubiquitin ligase for PIGL, is expressed at low levels in docetaxel-resistant prostate cancer.

  • 4

    Knockdown of HUWE1 enhances docetaxel resistance in prostate cancer, which can be reversed by silencing PIGL.

  • 5

    The study highlights the roles of PIGL and HUWE1 in prostate cancer progression and docetaxel resistance mechanisms.

Original Source(s)

PIGL promotes the docetaxel resistance of prostate cancer and is regulated by E3 ubiquitin ligase HUWE1

  • by Pan Gao, Bo-Han Lin, Zhi Zhang, Ze-Yu Yi, Zhi-Bin Ke, Zhong-Hua Zhu, Zhen Kang, Yong Wei

  • June 18, 2026

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