Comparative Transcriptional Profiling of Key Macrophage and Fibroblast Subpopulations in Rheumatoid Arthritis–Associated Lung Disease - Takeaways - MDSpire
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Differential Gene Expression Analysis of Major Macrophage and Fibroblast Subtypes in Lung Disease Related to Rheumatoid Arthritis

  • By

  • Tracy Tabib

  • Ogechukwu Ezenwa

  • Joshua Sciurba

  • Eleanor B. Valenzi

  • John Sembrat

  • Brittany Cody

  • Jishnu Das

  • Robert Lafyatis

  • Dana P. Ascherman

  • July 8, 2026

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  • 1

    Rheumatoid arthritis (RA) significantly impacts health, with interstitial lung disease (ILD) being a major extra-articular complication.

  • 2

    RA-ILD occurs nine times more frequently than in matched controls and accounts for 10% to 20% of excess mortality in RA.

  • 3

    Advanced RA-ILD shares histopathologic features with idiopathic pulmonary fibrosis (IPF), including poor survival rates.

  • 4

    Machine learning tools have identified protein mediators that distinguish RA-ILD from RA without ILD, even in subclinical cases.

  • 5

    Single-cell RNA sequencing has been utilized to analyze transcriptomic profiles in RA-ILD, revealing macrophage and fibroblast interactions.

Original Source(s)

Comparative Transcriptional Profiling of Key Macrophage and Fibroblast Subpopulations in Rheumatoid Arthritis–Associated Lung Disease

  • by Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman

  • July 8, 2026

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