Degeneration rather than hypoplasia may be the pathologic feature of the endolymphatic sac in patients with ipsilateral delayed endolymphatic hydrops - Takeaways - MDSpire

Pathological Characteristics of the Endolymphatic Sac in Patients with Ipsilateral Delayed Endolymphatic Hydrops: Emphasizing Degeneration Over Hypoplasia

  • By

  • Kaijun Xia

  • Ping Lei

  • Qin Liu

  • Yingzhao Liu

  • Cen Chen

  • Xiaoye Chen

  • Xingqian Shen

  • Ziying Xu

  • Bo Liu

  • Hongjun Xiao

  • Yangming Leng

  • July 21, 2026

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  • 1

    The study investigates the prevalence of angular trajectory of the vestibular aqueduct (ATVA) in patients with ipsilateral delayed endolymphatic hydrops (DEH) and Ménière’s disease (MD).

  • 2

    Ipsilateral DEH patients showed a higher frequency of ATVA ≤ 120° compared to unilateral MD patients, indicating a potential dominance of degenerative endolymphatic sac pathology.

  • 3

    The distribution of ATVA categories in affected ears of ipsilateral DEH patients was not significantly different from control ears.

  • 4

    The study enrolled 27 ipsilateral DEH patients, 114 unilateral MD patients, and 45 control participants to assess clinical features and ATVA categories.

  • 5

    Findings suggest that degenerative endolymphatic sac may be the primary pathological type in ipsilateral DEH patients based on ATVA prevalence.

Original Source(s)

Degeneration rather than hypoplasia may be the pathologic feature of the endolymphatic sac in patients with ipsilateral delayed endolymphatic hydrops

  • by Kaijun Xia, Ping Lei, Qin Liu, Yingzhao Liu, Cen Chen, Xiaoye Chen, Xingqian Shen, Ziying Xu, Bo Liu, Hongjun Xiao, Yangming Leng

  • July 21, 2026

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