EBNEO Commentary: Fraction of Inspired Oxygen During Resuscitation of Preterm Infants: A Commentary on TORPIDO 30/60 Trial - Takeaways - MDSpire
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EBNEO Commentary on Oxygen Concentration for Preterm Infant Resuscitation: Insights from the TORPIDO 30/60 Trial

  • By

  • Kaia Amoah

  • Kanekal Gautham

  • November 12, 2026

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  • 1

    The multicenter randomized TORPIDO 30/60 trial enrolled infants born at 23 to 28 weeks’ gestation and compared resuscitation starting at FiO₂ 0.3 or 0.6.

  • 2

    The trial found no association between initial FiO₂ concentration and death or brain injury at 36 weeks’ corrected gestational age.

  • 3

    Although the protocol was implemented, infants assigned to FiO₂ 0.3 had average FiO₂ levels by 5 minutes similar to those assigned to FiO₂ 0.6.

  • 4

    The trial did not report bronchopulmonary dysplasia, retinopathy of prematurity, or major disability at 2 to 3 years.

  • 5

    Post hoc exploratory analyses found a higher incidence of ventriculomegaly among infants assigned to FiO₂ 0.6.

Original Source(s)

EBNEO Commentary: Fraction of Inspired Oxygen During Resuscitation of Preterm Infants: A Commentary on TORPIDO 30/60 Trial

  • by Kaia Amoah, Kanekal Gautham

  • November 12, 2026

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