Progress and prospects for herpesvirus vaccination using gB antigens

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Vaccines targeting glycoprotein B (gB) show promise for herpesvirus infections, particularly for Epstein-Barr Virus, human cytomegalovirus, and herpes simplex viruses.
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gB is a conserved protein across herpesviruses, playing a crucial role in membrane fusion during viral entry into host cells.
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Recent advancements in stabilizing the pre-fusion conformation of gB may enhance immunological protection in vaccine development.
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Current gB-targeting vaccines have received less attention compared to those targeting receptor-binding glycoproteins like EBV gH/gL.
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The review highlights the need for further exploration of gB as a vaccine antigen and its potential compared to alternative vaccine strategies.

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