Epidemiology, Genetic Features, and Prognosis of Pediatric Cardiomyopathy in a National Cohort (2003–2025)

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Pediatric cardiomyopathy is a rare condition with diverse presentations, primarily including dilated and hypertrophic cardiomyopathy.
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The incidence of pediatric cardiomyopathy is estimated at around 1 in 100,000 children, with DCM being the leading cause of pediatric heart transplantation.
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Eighty-four children were diagnosed with various types of pediatric cardiomyopathy, with a median age at diagnosis of 2 years.
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Sixty-two children were included in incidence analyses, revealing a mean annual incidence of 0.9 per 100,000 children for DCM and HCM.
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Genetic testing identified pathogenic variants in 61% of patients, with the majority being sarcomeric variants.

Pediatric Cardiology

by Scott Kendall, Shannon Scott, Peter McClung, Joy McCance, Nawab Ali, Gillian Rea, William Wright, Jane Murray, Alison Muir, Martin Dempster, Terrence Prendiville, Pascal McKeown, Frank Casey
June 26, 2026

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