Emerging applications of machine learning and AI for predictive modeling in precision medicine - Takeaways - MDSpire
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New Directions in Machine Learning and AI for Predictive Modeling in Precision Medicine

  • By

  • Jaime Zorraquin

  • Joseph C. Kvedar

  • Manuel Bange

  • Muthuraman Muthuraman

  • November 3, 2026

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  • 1

    The collection’s 31 contributions span video, physiological signals, digital health, and population health, emphasizing interpretable systems that integrate domain knowledge.

  • 2

    Portable video models support assessment of gait, autism, ophthalmologic conditions, ultrasound lesions, blood counts, and cardiovascular risk beyond laboratory settings.

  • 3

    Signal-analysis applications use lightweight and multimodal models to predict outcomes in neurology, psychiatry, and cardiology, including from ECGs and routine records.

  • 4

    Combining wearables, biomarkers, multi-omics, and electronic health records captures health complexity across applications such as Alzheimer disease, cancer, and frailty.

  • 5

    The authors identify mechanistic interpretability, human-centered explanations, prospective validation, adaptive regulation, and equitable deployment as priorities for clinical translation.

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