The TRUST trial in ovarian cancer: a missed opportunity or a turning point? The position of the Italian MITO group - Takeaways - MDSpire

The TRUST trial in ovarian cancer: a missed opportunity or a turning point? The position of the Italian MITO group

  • By

  • Martina Arcieri

  • Sandro Pignata

  • Domenica Lorusso

  • Anna Fagotti

  • Vito Chiantera

  • Antonino Ditto

  • Giorgio Valabrega

  • Claudia Marchetti

  • Claudio Zamagni

  • Valentina Tuninetti

  • Alberto Farolfi

  • Stefano Restaino

  • Giuseppe Vizzielli

  • May 28, 2026

  • 0 min

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  • 1

    The TRUST trial compared primary debulking surgery with neoadjuvant chemotherapy in advanced ovarian cancer but did not meet its primary overall survival endpoint.

  • 2

    Progression-free survival favored primary debulking surgery, indicating potential benefits when performed in carefully selected patients.

  • 3

    The trial's limitations included inadequate surgical candidate selection and reliance on overall survival as the sole primary endpoint.

  • 4

    Expert discussions emphasized the need for validated selection tools and caution against misinterpreting the trial's findings in low-volume centers.

  • 5

    The MITO group's insights highlight the importance of centralizing care in high-volume centers for optimal treatment matching in ovarian cancer.

Original Source(s)

The TRUST trial in ovarian cancer: a missed opportunity or a turning point? The position of the Italian MITO group

  • by Martina Arcieri, Sandro Pignata, Domenica Lorusso, Anna Fagotti, Vito Chiantera, Antonino Ditto, Giorgio Valabrega, Claudia Marchetti, Claudio Zamagni, Valentina Tuninetti, Alberto Farolfi, Stefano Restaino, Giuseppe Vizzielli

  • May 28, 2026

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