Integrative genetic and expression profiling prioritizes LIPA in mononuclear phagocytes as a candidate regulator of carotid plaque - Takeaways - MDSpire

Integrative genetic and expression profiling prioritizes LIPA in mononuclear phagocytes as a candidate regulator of carotid plaque

  • By

  • Zhuyuan Yu

  • Shuhua Mao

  • Ying Song

  • Xiangyuan Meng

  • Jianing Yu

  • Ziyu Zong

  • Tianlin Gao

  • Hao Chen

  • June 19, 2026

  • 0 min

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  • 1

    The study identifies 22 candidate genes associated with carotid plaque (CP) using genetic and expression profiling approaches.

  • 2

    LIPA_Mono_C shows a consistent causal association with increased CP risk across two independent GWAS datasets.

  • 3

    Single-cell RNA sequencing reveals high expression of LIPA in mononuclear phagocytes within CP tissues.

  • 4

    In vitro experiments demonstrate that LIPA knockdown reduces lipid accumulation and attenuates immune responses in macrophages.

  • 5

    The findings suggest LIPA's role in lipid metabolism and immune regulation in carotid plaque, warranting further validation.

Original Source(s)

Integrative genetic and expression profiling prioritizes LIPA in mononuclear phagocytes as a candidate regulator of carotid plaque

  • by Zhuyuan Yu, Shuhua Mao, Ying Song, Xiangyuan Meng, Jianing Yu, Ziyu Zong, Tianlin Gao, Hao Chen

  • June 19, 2026

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