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1
Natural killer (NK) cells exhibit daily variations in number and effector function, influenced by circadian timing.
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2
Circadian rhythms impact NK cell activity through hormonal regulation, including cortisol and adrenaline fluctuations.
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3
Acute sleep loss can temporarily increase NK activity, while prolonged sleep deprivation reduces NK counts and function.
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4
Circadian disruption, such as shift work, leads to decreased NK activity and altered transcriptional programs.
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5
Variability in NK cell responses is influenced by factors like age, sex, photoperiod, and specific disease states.
