Disruption of a GalR2–mitochondrial axis in the ventral hippocampus contributes to depression-like phenotypes after prenatal stress - Takeaways - MDSpire

Disruption of a GalR2–mitochondrial axis in the ventral hippocampus contributes to depression-like phenotypes after prenatal stress

  • By

  • Jingjing Yue

  • Jing Zhang

  • Xiaoyi Yu

  • Zhiheng Li

  • Yanhua Wang

  • Siyi Zhao

  • Yunfei Bai

  • Xiaoxiao Li

  • Hui Li

  • Yutao Yang

  • Zhi-Qing David Xu

  • June 8, 2026

  • 0 min

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  • 1

    Prenatal stress induces depression-like behaviors in adult offspring, linked to mitochondrial dysfunction in the ventral hippocampus.

  • 2

    GalR2 and PINK1/Parkin signaling are downregulated in the ventral hippocampus following prenatal stress, contributing to mitochondrial abnormalities.

  • 3

    Intranasal administration of the GalR2 agonist AR-M1896 partially restores reward-related behaviors and mitochondrial function in stressed offspring.

  • 4

    Direct infusion of AR-M1896 into the ventral hippocampus elevates ATP and PINK1/Parkin levels, confirming its role in mitochondrial quality control.

  • 5

    The study identifies a GalR2-mitochondrial axis in the ventral hippocampus as a potential mechanism linking early-life stress to long-term depression vulnerability.

Original Source(s)

Disruption of a GalR2–mitochondrial axis in the ventral hippocampus contributes to depression-like phenotypes after prenatal stress

  • by Jingjing Yue, Jing Zhang, Xiaoyi Yu, Zhiheng Li, Yanhua Wang, Siyi Zhao, Yunfei Bai, Xiaoxiao Li, Hui Li, Yutao Yang, Zhi-Qing David Xu

  • June 8, 2026

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