The impact of subtotal pancreatectomy on people with congenital hyperinsulinism and their caregivers - Takeaways - MDSpire

The impact of subtotal pancreatectomy on people with congenital hyperinsulinism and their caregivers

  • By

  • Kristen E. Rohli

  • Indraneel Banerjee

  • Henrik Thybo Christesen

  • Diva D. De Leon

  • Lauren N. Lopez

  • Julie Raskin

  • Tai L. S. Pasquini

  • June 22, 2026

  • 0 min

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  • 1

    Congenital hyperinsulinism (HI) leads to severe hypoglycemia and affects approximately 1 in 28,000 births.

  • 2

    Subtotal pancreatectomy is a treatment option for diffuse HI, often performed before two months of age.

  • 3

    At follow-up, 44% of participants reported diabetes and 41% reported pancreatic insufficiency after pancreatectomy.

  • 4

    Caregivers described post-surgery periods as stressful, impacting their mental health, while children reported less perceived burden.

  • 5

    Pancreatectomy for diffuse HI is not curative and results in lifelong management challenges and health consequences.

Original Source(s)

The impact of subtotal pancreatectomy on people with congenital hyperinsulinism and their caregivers

  • by Kristen E. Rohli, Indraneel Banerjee, Henrik Thybo Christesen, Diva D. De Leon, Lauren N. Lopez, Julie Raskin, Tai L. S. Pasquini

  • June 22, 2026

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