Comparative diagnostic performance of C-TIRADS versus Kwak TI-RADS for thyroid nodules: implications for fine-needle aspiration biopsy referral - Takeaways - MDSpire

Comparative diagnostic performance of C-TIRADS versus Kwak TI-RADS for thyroid nodules: implications for fine-needle aspiration biopsy referral

  • By

  • Li Xia

  • Anjie Chen

  • Li Kang

  • Shiming Guan

  • Qing Luy

  • June 4, 2026

  • 0 min

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  • 1

    The study evaluated the diagnostic efficacy of C-TIRADS compared to Kwak TI-RADS for thyroid nodules over a follow-up period from 2019 to 2024.

  • 2

    C-TIRADS demonstrated an AUC of 0.784, with a category of ≥4B yielding sensitivity of 75.72% and specificity of 75.76% for malignant nodules.

  • 3

    No significant difference in diagnostic efficacy was found between C-TIRADS and Kwak TI-RADS, reinforcing the clinical utility of both systems.

  • 4

    Microcalcifications, irregular margins, and internal vascularity were increasingly observed in nodules during follow-up, indicating potential malignancy.

  • 5

    Thyroid nodules in the study were predominantly multiple and bilaterally distributed, with a gradual increase in nodules exceeding 10 mm in diameter.

Original Source(s)

Comparative diagnostic performance of C-TIRADS versus Kwak TI-RADS for thyroid nodules: implications for fine-needle aspiration biopsy referral

  • by Li Xia, Anjie Chen, Li Kang, Shiming Guan, Qing Luy

  • June 4, 2026

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