A comparison of electrophysiological microrecording versus automatic MR-based segmentation to determine subthalamic nucleus boundaries

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Subthalamic nucleus deep brain stimulation is effective for Parkinson's disease, requiring precise lead placement for optimal clinical benefit.
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Microelectrode recording (MER) provides accurate STN boundary determination but is time-consuming and may increase intraoperative bleeding risk.
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Automatic MR-based segmentation using Brainlab ElementsTM offers a less invasive method for identifying STN boundaries with high accuracy.
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The study involved 78 Parkinson's patients, comparing intraoperative STN coordinates from MER and MR-based segmentation.
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Concordance between MER and MR-based methods was good, with 85.3% agreement on optimal trajectory selection for electrode placement.

Acta Neurochirurgica

by Camilla de Laurentis, Stéphane Thobois, Teodor Danaila, Chloe Laurencin, Gustavo Polo, Stéphane Prange, Emile Simon
July 22, 2025

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