Mass Spec Roundup: Proteoforms, PTMs, and Plasma - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Mass Spec Roundup: Proteoforms, PTMs, and Plasma

Mass spectrometry tackles selectivity at several levels, from mitochondrial protein processing and lipid cargo to targeted PTMs and plasma-assisted hydrocarbon analysis. 

  • September 2, 2026

  • 7 min

Share

  • 1

    N-terminal proteomics and complexome profiling link ICP55 processing to mitochondrial protein assembly stability.

  • 2

    The study identified 446 processed mitochondrial proteins and 107 high-confidence ICP55 substrates in human cells.

  • 3

    Loss of ICP55 significantly altered the profiles of 177 mitochondrial proteins, affecting large assemblies and smaller complexes.

  • 4

    Native mass spectrometry revealed distinct phospholipid preferences among STARD2, STARD7, and STARD10 transporters.

  • 5

    GoDig 2.0 enhanced high-throughput quantification of post-translational modifications, identifying significant tau phosphorylation differences in Alzheimer's samples.

Original Source(s)

Mass Spec Roundup: Proteoforms, PTMs, and Plasma

  • September 2, 2026

Related Content

Newborn variants may flag childhood cancer predisposition

Targeted sequencing identified cancer-risk variants in about 7% of pediatric patients who later developed early-onset solid or brain malignancies.

Tissue Clocks Link Aging With Disease

Models trained on histology images detected aging patterns in the brain, gastrointestinal tract, and other organs

  • August 26, 2026

  • 3 min
FDA expands essential thrombocythemia care

Phase 3 SURPASS ET data showed higher durable response rates with ropeginterferon alfa-2b-njft than with anagrelide.