VCTE vs. histology in MASLD
The study included 3,532 adults with MASLD.
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By
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Doug Brunk
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January 6, 2026
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1
VCTE-based liver stiffness measurement (LSM) predicts liver-related outcomes in MASLD with accuracy comparable to liver biopsy.
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2
The study analyzed 3,532 adults with MASLD, all of whom underwent both VCTE and liver biopsy at baseline.
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During a median follow-up of 56.6 months, 126 patients (3.6%) developed liver-related events, primarily due to hepatic decompensation.
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Five-year AUROC values for LSM and histology were nearly identical at 0.870 and 0.869, respectively.
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LSM may serve as a practical alternative to histology for prognostic endpoints in clinical trials and risk stratification.