Time-restricted eating versus calorie restriction for improving biomarkers of age in adults with overweight or obesity and incipient fatty liver disease: protocol for the ENSATI randomized controlled parallel groups trial. - Takeaways - MDSpire

Time-restricted eating versus calorie restriction for improving biomarkers of age in adults with overweight or obesity and incipient fatty liver disease: protocol for the ENSATI randomized controlled parallel groups trial.

  • By

  • Celada, José A.

  • Rubio-Gordón, Laura

  • Jiménez-Perez, Yolanda

  • López-Lora, Lorena

  • López-González, Andrés

  • Delbuono, Sara

  • Huertas, Ana

  • Martínez-Urbistondo, Diego

  • Ordovas, Jose M

  • de la O, Víctor

  • Daimiel, Lidia

  • May 28, 2026

  • 0 min

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  • 1

    The ENSATI trial is a randomized controlled study comparing time-restricted eating and caloric restriction in overweight or obese adults.

  • 2

    A total of 177 adults aged 50–70 with early fatty liver disease will participate in the trial over a 12-month period.

  • 3

    Primary outcomes include changes in body composition, hepatic fat, and metabolism, assessed through various validated methods.

  • 4

    Secondary outcomes will evaluate glucose regulation, gut microbiome profiles, and molecular biomarkers of aging.

  • 5

    The study aims to address limitations of previous research by employing a comprehensive and adequately powered design.

Original Source(s)

Time-restricted eating versus calorie restriction for improving biomarkers of age in adults with overweight or obesity and incipient fatty liver disease: protocol for the ENSATI randomized controlled parallel groups trial.

  • by Celada, José A., Rubio-Gordón, Laura , Jiménez-Perez, Yolanda , López-Lora, Lorena , López-González, Andrés , Delbuono, Sara , Huertas, Ana , Martínez-Urbistondo, Diego , Ordovas, Jose M, de la O, Víctor , Daimiel, Lidia

  • May 28, 2026

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