The Relationship Between Gut Microbiota and Diabetic Retinopathy: Insights from a Systematic Review and Meta-Analysis - Takeaways - MDSpire

The Relationship Between Gut Microbiota and Diabetic Retinopathy: Insights from a Systematic Review and Meta-Analysis

  • By

  • Reza Sadeghi

  • Mohammad Reza Abdol Homayuni

  • Abolfazl Fateh

  • Nayereh Ebrahimzadeh

  • Hamid Riazi-Esfahani

  • Mohammad Yazdani Moghadam

  • Reza Nikfar

  • Pedram Pakzamir

  • Seyed Davar Siadat

  • January 3, 2026

  • 0 min

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  • 1

    Gut microbiota, primarily from Firmicutes and Bacteroidetes, play a crucial role in human physiological processes and health.

  • 2

    Diabetes Mellitus significantly alters gut microbiota composition, leading to dysbiosis, which can exacerbate complications like diabetic retinopathy.

  • 3

    Diabetic retinopathy is a major cause of vision impairment, affecting approximately 35% of individuals with diabetes.

  • 4

    Emerging evidence suggests a gut-eye axis where gut microbiota influence retinal health through systemic inflammation and microbial metabolites.

  • 5

    This systematic review aims to evaluate the correlation between gut microbiota changes and the severity and prognosis of diabetic retinopathy.

Original Source(s)

The Relationship Between Gut Microbiota and Diabetic Retinopathy: Insights from a Systematic Review and Meta-Analysis

  • by Reza Sadeghi, Mohammad Reza Abdol Homayuni, Abolfazl Fateh, Nayereh Ebrahimzadeh, Hamid Riazi-Esfahani, Mohammad Yazdani Moghadam, Reza Nikfar, Pedram Pakzamir, Seyed Davar Siadat

  • January 3, 2026

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