Efficacy and Mechanisms of Tripterygium wilfordii Hook. f. and Xinfeng Capsule in the Management of Rheumatoid Arthritis: A Comprehensive Review of Clinical Evidence and Translational Insights

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Tripterygium wilfordii Hook. f. (TWHf) is traditionally used for rheumatoid arthritis (RA) but requires a comprehensive understanding of its efficacy and safety.
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The review summarizes clinical evidence and mechanisms of TWHf-derived compounds, including Tripterygium Glycosides Tablets and Xinfeng Capsule in RA management.
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Preclinical studies show TWHf compounds regulate RA-related processes through various signaling pathways and immune responses.
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Xinfeng Capsule demonstrates broader regulatory effects compared to isolated monomers, enhancing efficacy and reducing toxicity.
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Challenges in TWHf application include toxicity, lack of high-quality trials, and need for standardized formulations and personalized dosing.

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