Spatiotemporal Origin and Cross-Regional Transmission Dynamics of HIV-1 Circulating Recombinant Form (CRF85_BC) in Developed Eastern China: A Seven-Year Comprehensive Molecular Surveillance Study - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Geographic and Temporal Origins and Spread of HIV-1 CRF85_BC Across Developed Eastern China: Findings from Seven Years of Molecular Surveillance

  • By

  • Qin Fan

  • Jiafeng Zhang

  • Jun Jiang

  • Hehe Zhao

  • Xiaohong Pan

  • Hui Xing

  • Yaping Yao

  • Yi Feng

  • Yong Yan

  • Xiaobei Ding

  • Wei Cheng

  • Xin Zhou

  • Yan Xia

  • Chengliang Chai

  • Jianmin Jiang

  • October 24, 2026

Share

  • 1

    This study analyzed 259 people with CRF85_BC infection identified through Zhejiang Province’s HIV molecular surveillance from 2017 through 2023.

  • 2

    CRF85_BC was detected in Zhejiang in 2017 and had reached all 11 prefecture-level cities by 2023, becoming the province’s fifth most prevalent HIV-1 subtype.

  • 3

    Phylogeographic analysis indicated multiple introductions from Sichuan and Yunnan, followed by sustained transmission within Zhejiang centered on Jiaxing.

  • 4

    Molecular network analysis identified 183 people (70.66%) in 41 clusters. Jiaxing accounted for 48.63% of clustered cases; 58.60% of genetic linkages connected two Jiaxing cases.

  • 5

    Adults aged 60 years or older had higher clustering before adjustment, but age was not independently associated afterward. Nonlocal household registration remained associated with lower clustering odds.

Original Source(s)

Spatiotemporal Origin and Cross-Regional Transmission Dynamics of HIV-1 Circulating Recombinant Form (CRF85_BC) in Developed Eastern China: A Seven-Year Comprehensive Molecular Surveillance Study

  • by Qin Fan, Jiafeng Zhang, Jun Jiang, Hehe Zhao, Xiaohong Pan, Hui Xing, Yaping Yao, Yi Feng, Yong Yan, Xiaobei Ding, Wei Cheng, Xin Zhou, Yan Xia, Chengliang Chai, Jianmin Jiang

  • October 24, 2026

Related Content

Much of the excess mortality in immunocompromised patients with viral severe acute respiratory infection occurs after ICU discharge

Medical Oddities: The ghost that haunted a heart

From haunted hearts to toxic treats, medicine has a few Halloween tricks up its sleeve.

Standardizing pneumonia response does not by itself define the treatment estimand