Feasibility of embryonic-natural orifice transluminal endoscopic surgery for submucosal tumors with mucosal preservation in beagle model - Takeaways - MDSpire

Feasibility of embryonic-natural orifice transluminal endoscopic surgery for submucosal tumors with mucosal preservation in beagle model

  • By

  • Han Lin

  • Chuan-Shen Jiang

  • Dong-Gui Hong

  • Long-Ping Chen

  • Yan Zhuang

  • Wen Lin

  • Zan-Xuan Qiu

  • Xin-Yi Zheng

  • Meng-Yao Xu

  • Li-Li Wu

  • Yang-Xin Xie

  • Wen Wang

  • Xiao-Jian He

  • Da-Zhou Li

  • April 9, 2026

  • 0 min

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  • 1

    E-NOTES is a novel technique designed to resect muscularis propria-originating submucosal tumors while preserving mucosal integrity.

  • 2

    In a study with twelve beagles, E-NOTES successfully resected simulated gastric lesions without severe complications.

  • 3

    The mean operative time for E-NOTES was 64.3 minutes, with minor intraoperative bleeding occurring in 58.3% of cases.

  • 4

    Postoperative evaluations confirmed complete mucosal healing and successful excision of targeted tumors after 60 days.

  • 5

    E-NOTES demonstrated minimal invasiveness, low complication rates, and rapid recovery, supporting further research in translational studies.

Original Source(s)

Feasibility of embryonic-natural orifice transluminal endoscopic surgery for submucosal tumors with mucosal preservation in beagle model

  • by Han Lin, Chuan-Shen Jiang, Dong-Gui Hong, Long-Ping Chen, Yan Zhuang, Wen Lin, Zan-Xuan Qiu, Xin-Yi Zheng, Meng-Yao Xu, Li-Li Wu, Yang-Xin Xie, Wen Wang, Xiao-Jian He, Da-Zhou Li

  • April 9, 2026

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