T cell dysfunction and metabolic disruption in chronic hepatitis C virus infection - Takeaways - MDSpire

T cell dysfunction and metabolic disruption in chronic hepatitis C virus infection

  • By

  • Bhavya Sajeet

  • Uma Ganapathi

  • Kiruthika Naganathan

  • Aarthi Parthasarathy

  • Pramod Darvin

  • Varun Sasidharan Nair

  • June 1, 2026

  • 0 min

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  • 1

    HCV infection is a major global health issue, leading to chronic liver disease, cirrhosis, and hepatocellular carcinoma.

  • 2

    Chronic HCV infection causes T cell dysfunction characterized by reduced proliferation and increased inhibitory receptor expression.

  • 3

    Regulatory T cells accumulate in the liver, further suppressing antiviral immune responses and promoting viral persistence.

  • 4

    Chronic HCV infection induces metabolic dysfunction, including oxidative stress and impaired bioenergetics, affecting T cell responses.

  • 5

    Some immune defects persist post-viral eradication due to stable transcriptional and epigenetic changes in exhausted T cells.

Original Source(s)

T cell dysfunction and metabolic disruption in chronic hepatitis C virus infection

  • by Bhavya Sajeet, Uma Ganapathi, Kiruthika Naganathan, Aarthi Parthasarathy, Pramod Darvin, Varun Sasidharan Nair

  • June 1, 2026

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