Training on PD-L1 scoring in non-small cell lung cancer with high intra- and inter-reader agreement: results of a worldwide microscopic/digital image-based training of 751 pathologists - Takeaways - MDSpire

Training on PD-L1 scoring in non-small cell lung cancer with high intra- and inter-reader agreement: results of a worldwide microscopic/digital image-based training of 751 pathologists

  • By

  • Gudrun Bänfer

  • Rolf Diezko

  • Rabea Oberthür

  • George L. Kumar

  • Josef Rüschoff

  • Hans-Ulrich Schildhaus

  • Bharat Jasani

  • June 8, 2026

  • 0 min

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  • 1

    A global training initiative involved 751 pathologists from 63 countries to standardize PD-L1 scoring in non-small cell lung cancer.

  • 2

    The training achieved high inter-reader agreement of 95.6% for TPS ≥1% and 87.3% for TPS ≥50% in PD-L1 stained NSCLC.

  • 3

    Intra-reader agreement was also high, with 95.9% for TPS ≥1% and 91.4% for TPS ≥50%, indicating reliable scoring consistency.

  • 4

    The training utilized both glass slides and digital images, enhancing accessibility and allowing remote participation for pathologists.

  • 5

    This initiative highlights the importance of expert-led training to reduce variability in PD-L1 scoring, crucial for effective NSCLC treatment.

Original Source(s)

Training on PD-L1 scoring in non-small cell lung cancer with high intra- and inter-reader agreement: results of a worldwide microscopic/digital image-based training of 751 pathologists

  • by Gudrun Bänfer, Rolf Diezko, Rabea Oberthür, George L. Kumar, Josef Rüschoff, Hans-Ulrich Schildhaus, Bharat Jasani

  • June 8, 2026

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