Structural and functional dissection of neutralisation differences among SARS-CoV-2 variants using antigenicity prediction and CR3022 binding analysis - Takeaways - MDSpire
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Analysis of Structural and Functional Variations in Neutralization Among SARS-CoV-2 Variants Through Antigenicity Prediction and CR3022 Binding Assessment

  • By

  • Jyoti Sawant

  • Ajit Patil

  • Madhuri Thakar

  • Swarali Kurle

  • July 6, 2026

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  • 1

    SARS-CoV-2 variants exhibit mutations in the spike glycoprotein, affecting antibody recognition and vaccine-induced protection.

  • 2

    Neutralisation responses varied among cohorts of naturally infected, vaccinated, and vaccinated-infected individuals.

  • 3

    Plasma from vaccinated individuals showed higher neutralisation titres, while Delta and Omicron variants had reduced susceptibility to neutralisation.

  • 4

    Computational analyses revealed variant-associated differences in predicted antigenicity and epitope landscapes within the spike protein.

  • 5

    The study integrates experimental and computational methods to characterize variant-specific neutralisation across different immune exposure histories.

Original Source(s)

Structural and functional dissection of neutralisation differences among SARS-CoV-2 variants using antigenicity prediction and CR3022 binding analysis

  • by Jyoti Sawant, Ajit Patil, Madhuri Thakar, Swarali Kurle

  • July 6, 2026

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