Evaluating Cognitive Effects and Anti-Inflammatory Mechanisms of Deep Brain Stimulation in the Nucleus Basalis of Meynert for Alzheimer’s Disease

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Deep brain stimulation of the nucleus basalis of Meynert (NBM-DBS) is a potential treatment for Alzheimer’s disease (AD) with variable clinical outcomes.
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In a trial, patients with moderate AD maintained cognitive performance, while those with severe AD showed significant decline over 12 months.
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Serum analyses revealed increased anti-inflammatory cytokines IL-10 and IL-27, and decreased pro-inflammatory chemokines after NBM-DBS.
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The study suggests that NBM-DBS may stabilize cognitive function in moderate AD through modulation of inflammation.
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The therapeutic effects of NBM-DBS appear more pronounced in patients with moderate AD compared to those with severe AD.

Frontiers In Neurology

by Yingchuan Chen, Tingting Du, Tenghong Lian, Yin Jiang, Tianshuo Yuan, Jing Li, Fangang Meng, Anchao Yang, Wei Zhang, Jianguo Zhang
April 22, 2026

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