Factors influencing abnormal cleavage of early embryos: time-lapse imaging analysis of 138,178 normally fertilized embryos - Takeaways - MDSpire

Factors influencing abnormal cleavage of early embryos: time-lapse imaging analysis of 138,178 normally fertilized embryos

  • By

  • Weiwei Liu

  • Jun Shuai

  • Yang Gao

  • Qi Zhang

  • Xiaoni Guo

  • Wei Han

  • Guoning Huang

  • May 15, 2026

  • 0 min

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  • 1

    Abnormal cleavage (ABNCL) occurs in 44.1% of early human embryos and is linked to reduced developmental competence.

  • 2

    Factors such as endometriosis, unexplained infertility, and higher oocyte yield increase the risk of ABNCL.

  • 3

    Mild stimulation protocols and higher estradiol levels on the hCG trigger day are associated with a reduced risk of ABNCL.

  • 4

    Different ABNCL subtypes show distinct associations with gonadotropin doses and stimulation protocols.

  • 5

    The study emphasizes the need for individualized controlled ovarian stimulation strategies to enhance embryo development.

Original Source(s)

Factors influencing abnormal cleavage of early embryos: time-lapse imaging analysis of 138,178 normally fertilized embryos

  • by Weiwei Liu, Jun Shuai, Yang Gao, Qi Zhang, Xiaoni Guo, Wei Han, Guoning Huang

  • May 15, 2026

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