Association Between Cigarette Smoking and SARS-CoV-2 Infection: Insights from Multivariable Regression and Mendelian Randomization in the Norwegian Mother, Father and Child Cohort Study - Takeaways - MDSpire

Association Between Cigarette Smoking and SARS-CoV-2 Infection: Insights from Multivariable Regression and Mendelian Randomization in the Norwegian Mother, Father and Child Cohort Study

  • By

  • Ida Henriette Caspersen

  • Álvaro Hernáez

  • Sebastián Peña

  • Ahmed Nabil Shaaban

  • Maria Christine Magnus

  • Sakari Karvonen

  • Maria Rosaria Galanti

  • Per Magnus

  • February 4, 2026

  • 0 min

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  • 1

    Smokers infected with SARS-CoV-2 had higher risks of severe disease and long-lasting effects compared to non-smokers.

  • 2

    Observational studies show current smokers have a lower risk of testing positive for SARS-CoV-2 than non-smokers.

  • 3

    Mendelian randomization studies indicate a positive association between genetically predicted smoking traits and SARS-CoV-2 infection.

  • 4

    Discrepancies between MR studies and observational studies may arise from confounding factors or violations of MR assumptions.

  • 5

    The study utilized data from the Norwegian Mother, Father, and Child Cohort Study to analyze smoking traits and SARS-CoV-2 infection risk.

Original Source(s)

Association Between Cigarette Smoking and SARS-CoV-2 Infection: Insights from Multivariable Regression and Mendelian Randomization in the Norwegian Mother, Father and Child Cohort Study

  • by Ida Henriette Caspersen, Álvaro Hernáez, Sebastián Peña, Ahmed Nabil Shaaban, Maria Christine Magnus, Sakari Karvonen, Maria Rosaria Galanti, Per Magnus

  • February 4, 2026

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