Case Report: A diabetic ketoacidosis in adolescents complicated with rhino-orbital-cerebral mucormycosis - Takeaways - MDSpire

Case Report: A diabetic ketoacidosis in adolescents complicated with rhino-orbital-cerebral mucormycosis

  • By

  • Jinxin Tang

  • Qishu Hou

  • Jifeng Ye

  • Yueyue Weng

  • July 14, 2026

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  • 1

    Rhino-orbital-cerebral mucormycosis (ROCM) is a severe infection with high mortality, particularly in patients with diabetes.

  • 2

    A 14-year-old female with type 1 diabetes developed ROCM following diabetic ketoacidosis, presenting with atypical symptoms.

  • 3

    Diagnosis of ROCM was confirmed through plasma mNGS and nasal mucosa biopsy, detecting Rhizopus delemar.

  • 4

    The treatment involved liposomal amphotericin B and nasal endoscopic debridement, later adjusted to include isavuconazole.

  • 5

    Clinical pharmacists played a vital role in optimizing antifungal regimens and monitoring for adverse drug reactions during treatment.

Original Source(s)

Case Report: A diabetic ketoacidosis in adolescents complicated with rhino-orbital-cerebral mucormycosis

  • by Jinxin Tang, Qishu Hou, Jifeng Ye, Yueyue Weng

  • July 14, 2026

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