The Role of Cortisol Secretion in Pheochromocytomas and Paragangliomas: Clinical and Perioperative Implications - Takeaways - MDSpire

The Role of Cortisol Secretion in Pheochromocytomas and Paragangliomas: Clinical and Perioperative Implications

  • By

  • Karolina Zawadzka

  • Jan Calissendorff

  • Ewelina Rzepka

  • Michał Pędziwiatr

  • Alicja Hubalewska-Dydejczyk

  • Henrik Falhammar

  • June 19, 2025

  • 0 min

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  • 1

    Pheochromocytomas and paragangliomas (PPGLs) are characterized by excessive catecholamine secretion, impacting cardiovascular and metabolic health.

  • 2

    24.5% of patients with PPGLs exhibited nonsuppressive cortisol concentrations, indicating mild autonomous cortisol secretion (MACS) post-dexamethasone suppression test.

  • 3

    Patients with nonsuppressive cortisol had larger tumors, higher diabetes prevalence, and more cardiovascular diseases compared to suppressive counterparts.

  • 4

    Perioperative complications were more frequent in the nonsuppressive group, including increased blood loss and longer hospital stays.

  • 5

    Routine dexamethasone suppression testing may enhance preoperative management and understanding of cortisol's effects on PPGL outcomes.

Original Source(s)

The Role of Cortisol Secretion in Pheochromocytomas and Paragangliomas: Clinical and Perioperative Implications

  • by Karolina Zawadzka, Jan Calissendorff, Ewelina Rzepka, Michał Pędziwiatr, Alicja Hubalewska-Dydejczyk, Henrik Falhammar

  • June 19, 2025

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