Ocular manifestations and immunological profiles of thyroid eye disease with lacrimal gland enlargement - Takeaways - MDSpire

Ocular manifestations and immunological profiles of thyroid eye disease with lacrimal gland enlargement

  • By

  • Yan Sun

  • Fan Shi

  • Congyao Wang

  • Xia Dong

  • Yihua Su

  • Fenfen Yu

  • Shubin Hong

  • Dide Wu

  • Mengsha Zou

  • Zhiyun Yang

  • Haipeng Xiao

  • Pengxia Wan

  • July 15, 2026

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  • 1

    Thyroid eye disease (TED) is an autoimmune condition commonly associated with Graves' disease, affecting the lacrimal glands and orbital tissues.

  • 2

    In a study of 123 TED patients, those with enlarged lacrimal glands exhibited worse proptosis and unstable tear film compared to those with normal glands.

  • 3

    Elevated thyroid peroxidase antibody (TPO-Ab) levels and increased proportions of CD8+ T cells and regulatory T cells were observed in patients with enlarged lacrimal glands.

  • 4

    Serum TPO-Ab levels and regulatory T cell proportions were significantly correlated with the area of the lacrimal gland in TED patients.

  • 5

    Regulatory T cell frequency emerged as a potential predictive biomarker for lacrimal gland involvement in patients with thyroid eye disease.

Original Source(s)

Ocular manifestations and immunological profiles of thyroid eye disease with lacrimal gland enlargement

  • by Yan Sun, Fan Shi, Congyao Wang, Xia Dong, Yihua Su, Fenfen Yu, Shubin Hong, Dide Wu, Mengsha Zou, Zhiyun Yang, Haipeng Xiao, Pengxia Wan

  • July 15, 2026

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