cGAS-STING pathway in innate immunity and its cell-specific role in kidney diseases

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The cGAS-STING signaling pathway is essential for detecting cytoplasmic DNA and initiating immune responses in the innate immune system.
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Activation of the cGAS-STING pathway drives inflammation, fibrosis, and cell damage in various renal cell types, contributing to kidney disease progression.
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Dysregulated activation of the cGAS-STING pathway is linked to the pathogenesis of inflammatory, autoimmune, and metabolic disorders.
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The cGAS enzyme synthesizes cyclic GMP-AMP upon detecting abnormal DNA, activating STING and triggering downstream immune responses.
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Research on the cGAS-STING pathway aims to transition targeted therapies from basic research to clinical applications for kidney diseases.

Frontiers In Immunology

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