Understanding Weaning Outcomes and Ventilation Duration in the PRiVENT Study

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The PRiVENT specialist-led weaning programme was feasible across a regional intensive care network.
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Weaning success was 58.3% among intervention patients and 51.7% among controls; the adjusted odds ratio was 1.46 (95% CI, 0.99–2.17; P = .057).
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A prespecified matched analysis found a larger association with weaning success (adjusted odds ratio, 2.90; 95% CI, 1.61–5.24), but residual confounding limits causal interpretation.
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The adjusted competing-risk analysis did not show a clear difference in cumulative weaning incidence (subdistribution hazard ratio, 1.12; 95% CI, 0.91–1.38; P = .30).
5

Median observed ventilation time was 456 hours in the intervention cohort and 342 hours in controls, with an adjusted difference of 81 hours (95% CI, 49–114).

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