Effects of Achieving Sustained Virological Response on Outcomes Following Hepatectomy for Hepatitis C-Associated Hepatocellular Carcinoma: A Retrospective Analysis

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Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, often diagnosed at advanced stages due to lack of early symptoms.
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Chronic hepatitis C virus (HCV) infection significantly increases the risk of HCC and related mortality, but direct-acting antivirals can cure HCV.
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Sustained virological response (SVR) is defined as undetectable HCV RNA 12 weeks post-antiviral therapy and is associated with improved survival in HCC patients.
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This study analyzed 75 patients with HCV-related HCC who underwent hepatectomy, comparing outcomes between those treated with direct-acting antivirals and untreated patients.
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The research aims to clarify the impact of achieving SVR on post-hepatectomy outcomes and identify independent risk factors affecting prognosis.

Bmc Infectious Diseases

by Pei-shu Li, Guo-dong Yang, Xiu-nan Huang, Xin-yuan Wu, Yi-fan Li, Ming-jian Huang, Jie Zhang, Bang-de Xiang
January 27, 2026

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