High serum FSH levels on day 7 of stimulation are negatively associated with oocyte retrieval in GnRH antagonist protocols: real-world evidence from 9,969 IVF cycles in China - Takeaways - MDSpire

High serum FSH levels on day 7 of stimulation are negatively associated with oocyte retrieval in GnRH antagonist protocols: real-world evidence from 9,969 IVF cycles in China

  • By

  • Xiu Luo

  • Hong Ye

  • Li Pei

  • Yao He

  • Fujie Li

  • Wei Han

  • Shun Xiong

  • Shubiao Han

  • Jingyu Li

  • Xiaodong Zhang

  • Guoning Huang

  • May 5, 2026

  • 0 min

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  • 1

    The study analyzed 9,969 IVF cycles to assess the relationship between serum FSH levels on Day 7 and oocyte retrieval outcomes.

  • 2

    Serum FSH levels below 9.13 mIU/mL were associated with increased oocyte retrieval, while levels above this threshold correlated with reduced oocyte collection.

  • 3

    Each 1 mIU/mL increase in serum FSH above 9.13 mIU/mL decreased oocyte retrieval by 0.07, indicating a negative impact on ovarian response.

  • 4

    Conversely, serum FSH levels below 9.13 mIU/mL showed a positive correlation, with each 1 mIU/mL increase leading to 1.18 more oocytes collected.

  • 5

    The findings suggest that adjusting FSH doses based on serum levels could optimize ovarian response in IVF protocols using GnRH antagonists.

Original Source(s)

High serum FSH levels on day 7 of stimulation are negatively associated with oocyte retrieval in GnRH antagonist protocols: real-world evidence from 9,969 IVF cycles in China

  • by Xiu Luo, Hong Ye, Li Pei, Yao He, Fujie Li, Wei Han, Shun Xiong, Shubiao Han, Jingyu Li, Xiaodong Zhang, Guoning Huang

  • May 5, 2026

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