Resting-state functional connectivity and local activity differences across bothersome and non-bothersome tinnitus phenotypes - Takeaways - MDSpire

Resting-state functional connectivity and local activity differences across bothersome and non-bothersome tinnitus phenotypes

  • By

  • Yongpeng Li

  • Lu Peng

  • Ying Lan

  • Binyu Mo

  • Shihua Yin

  • June 11, 2026

  • 0 min

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  • 1

    The study compared resting-state functional differences in bothersome tinnitus (BT), non-bothersome tinnitus (NBT), and non-tinnitus controls.

  • 2

    Significant functional connectivity differences were found between BT and NBT, particularly in the bilateral temporal lobe and left ACC/mOFC.

  • 3

    Lower regional homogeneity values were observed in NBT compared to both BT and non-tinnitus controls in the medial superior frontal gyrus.

  • 4

    fALFF analyses indicated region-specific differences across various brain regions, most notably between BT and NBT.

  • 5

    Findings suggest that imaging differences may reflect tinnitus loudness or related clinical burden rather than being specific to BT.

Original Source(s)

Resting-state functional connectivity and local activity differences across bothersome and non-bothersome tinnitus phenotypes

  • by Yongpeng Li, Lu Peng, Ying Lan, Binyu Mo, Shihua Yin

  • June 11, 2026

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