Liver stiffness measurements predict Sinusoidal Obstructive Syndrome after hematopoietic stem cell transplantation

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Sinusoidal Obstructive Syndrome (SOS) occurs in approximately 10% of adults after hematopoietic stem cell transplantation, with severe cases having an 80% mortality rate.
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Liver stiffness measurement (LSM) is a non-invasive tool that can help assess liver fibrosis but has limited use in diagnosing SOS after HSCT.
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The study aimed to evaluate LSM's ability to guide conditioning regimen selection and its diagnostic accuracy for SOS in patients post-allo-HSCT.
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Patients with LSM values above 7 kPa had their treatment adjusted to lower toxicity options to mitigate the risk of developing SOS.
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The study included 28 patients, with 11 assessed for SOS risk before HSCT and 18 evaluated after HSCT due to elevated bilirubin levels.

Bone Marrow Transplantation

by Yana Davidov, Noga Shem-Tov, Ronit Yerushalmi, Tammy Hod, Ziv Ben-Ari, Arnon Nagler, Avichai Shimoni, Ivetta Danylesko
April 24, 2024

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