Natural therapeutics and traditional formulas targeting macrophage polarization in the fibrotic niche of idiopathic pulmonary fibrosis - Takeaways - MDSpire

Natural therapeutics and traditional formulas targeting macrophage polarization in the fibrotic niche of idiopathic pulmonary fibrosis

  • By

  • Lei Han

  • Yifeng Sun

  • Yun Wang

  • Qian Wang

  • Xi Zhang

  • Huan He

  • Jia Wang

  • June 30, 2026

  • 0 min

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  • 1

    Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by fibrotic remodeling and poor prognosis.

  • 2

    Current FDA-approved antifibrotic agents, nintedanib and pirfenidone, do not reverse fibrosis and have significant adverse effects.

  • 3

    Macrophages play a crucial role in the fibrotic niche, exhibiting heterogeneity and plasticity that influence disease progression.

  • 4

    Natural product-based therapeutics are being explored as multi-targeted approaches to modulate macrophage polarization in IPF.

  • 5

    Future research should focus on empirical validation of natural therapies using advanced methodologies like metabolomics and transcriptomics.

Original Source(s)

Natural therapeutics and traditional formulas targeting macrophage polarization in the fibrotic niche of idiopathic pulmonary fibrosis

  • by Lei Han, Yifeng Sun, Yun Wang, Qian Wang, Xi Zhang, Huan He, Jia Wang

  • June 30, 2026

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