S-GRAS score and the complementary prognostic value of neutrophil-to-lymphocyte ratio in adrenocortical carcinoma: evidence for a synergistic interaction - Takeaways - MDSpire

S-GRAS score and the complementary prognostic value of neutrophil-to-lymphocyte ratio in adrenocortical carcinoma: evidence for a synergistic interaction

  • By

  • Erik Bényei

  • Gergely Huszty

  • András Laki

  • Zsuzsanna Jakab

  • Gergely Kiss

  • Attila Kristóf Kovács

  • Katalin Borka

  • Andrea Uhlyarik

  • Katalin Eitler

  • Peter Igaz

  • Judit Tőke

  • Miklós Tóth

  • June 8, 2026

  • 0 min

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  • 1

    The study evaluated the prognostic significance of the S-GRAS score and inflammation-based scores in adrenocortical carcinoma.

  • 2

    External validation showed the S-GRAS score had superior discriminative ability (C-index=0.765) compared to its individual components.

  • 3

    NLR was identified as a significant predictor of mortality in adrenocortical carcinoma patients, while PLR did not reach statistical significance.

  • 4

    The combination of S-GRAS and NLR provided superior prognostic discrimination (C-index=0.822) compared to either score alone.

  • 5

    A significant synergistic interaction between S-GRAS and NLR was observed, particularly in high-risk patient groups.

Original Source(s)

S-GRAS score and the complementary prognostic value of neutrophil-to-lymphocyte ratio in adrenocortical carcinoma: evidence for a synergistic interaction

  • by Erik Bényei, Gergely Huszty, András Laki, Zsuzsanna Jakab, Gergely Kiss, Attila Kristóf Kovács, Katalin Borka, Andrea Uhlyarik, Katalin Eitler, Peter Igaz, Judit Tőke, Miklós Tóth

  • June 8, 2026

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