Editorial: Multi-omics interrogation of tumor-associated macrophages: paving the way for next-generation cancer immunotherapies - Takeaways - MDSpire

Editorial: Exploring Multi-Omics Approaches to Tumor-Associated Macrophages: A Pathway to Advanced Cancer Immunotherapy

By
Shengshan Xu
Ke-Jie He
Lin Zhang
Qian Guo
August 25, 2026

Frontiers In Immunology

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1

Tumor-associated macrophages (TAMs) are key coordinators of immunosuppression within the tumor microenvironment.
2

High-resolution multi-omics approaches reveal significant heterogeneity and plasticity among TAM populations.
3

Machine-learning integration of multi-omics datasets has enabled robust prognostic modeling centered on TAMs.
4

Novel biomarkers and therapeutic targets, such as GPR35 and TIMP1, have been identified for potential cancer immunotherapy.
5

Environmental factors, like occupational silica exposure, can influence macrophage-driven inflammatory signaling in tumors.

Original Source(s)

Frontiers In Immunology

Editorial: Multi-omics interrogation of tumor-associated macrophages: paving the way for next-generation cancer immunotherapies

by Shengshan Xu, Ke-Jie He, Lin Zhang, Qian Guo
August 25, 2026

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