Sex-dependent effects of psychedelics: review of evidence from rodent models - Takeaways - MDSpire

Sex-dependent effects of psychedelics: review of evidence from rodent models

  • By

  • Rafał Marecki

  • Wiktoria Zaniewska

  • Adam Hamed

  • Napoleon Waszkiewicz

  • Jacob J. Baker

  • Kacper Łukasiewicz

  • July 15, 2026

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  • 1

    Classic psychedelics exert effects through 5-HT2A receptor agonism, influencing neurobiological and behavioral changes.

  • 2

    Sex differences in pharmacodynamics and neurobiological responses to psychedelics are evident in rodent studies.

  • 3

    Behavioral outcomes from psychedelics often show stronger effects in females, influenced by ovarian cycle phase.

  • 4

    Divergent therapeutic or adverse outcomes of psychedelics, such as psilocybin and DMT, are observed based on sex.

  • 5

    Integrating sex-specific analyses in psychedelic research is essential for enhancing translational validity.

Original Source(s)

Sex-dependent effects of psychedelics: review of evidence from rodent models

  • by Rafał Marecki, Wiktoria Zaniewska, Adam Hamed, Napoleon Waszkiewicz, Jacob J. Baker, Kacper Łukasiewicz

  • July 15, 2026

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